L'orario della scadenza è relativo alla prima partita in programma
Round 1 A - Scadenza: 12/10/18, h.20
| Leinster Rugby | Wasps RFC |
| Bath Rugby | Toulouse |
| Exeter Chiefs | Munster Rugby |
| Montpellier | Edinburgh Rugby |
| Llanelli Scarlets | Racing-Metro 92 |
| Ulster Rugby | Leicester Tigers |
| Gloucester | Castres Olympique |
| Lyon Rugby | Cardiff Blues |
| Glasgow Warriors | Saracens |
| Toulon | Newcastle Falcons |
|
Round 1 B - Scadenza: 12/10/18, h.20
| Leinster Rugby | Wasps RFC |
| Bath Rugby | Toulouse |
| Exeter Chiefs | Munster Rugby |
| Montpellier | Edinburgh Rugby |
| Llanelli Scarlets | Racing-Metro 92 |
| Ulster Rugby | Leicester Tigers |
| Gloucester | Castres Olympique |
| Lyon Rugby | Cardiff Blues |
| Glasgow Warriors | Saracens |
| Toulon | Newcastle Falcons |
|
Round 2 A - Scadenza: 19/10/18, h.20
| Leicester Tigers | Llanelli Scarlets |
| Castres Olympique | Exeter Chiefs |
| Munster Rugby | Gloucester |
| Edinburgh Rugby | Toulon |
| Wasps RFC | Bath Rugby |
| Racing-Metro 92 | Ulster Rugby |
| Saracens | Lyon Rugby |
| Newcastle Falcons | Montpellier |
| Cardiff Blues | Glasgow Warriors |
| Toulouse | Leinster Rugby |
|
Round 2 B - Scadenza: 19/10/18, h.20
| Leicester Tigers | Llanelli Scarlets |
| Castres Olympique | Exeter Chiefs |
| Munster Rugby | Gloucester |
| Edinburgh Rugby | Toulon |
| Wasps RFC | Bath Rugby |
| Racing-Metro 92 | Ulster Rugby |
| Saracens | Lyon Rugby |
| Newcastle Falcons | Montpellier |
| Cardiff Blues | Glasgow Warriors |
| Toulouse | Leinster Rugby |
|
Round 3 A - Scadenza: 07/12/18, h.20
| Edinburgh Rugby | Newcastle Falcons |
| Llanelli Scarlets | Ulster Rugby |
| Exeter Chiefs | Gloucester |
| Lyon Rugby | Glasgow Warriors |
| Bath Rugby | Leinster Rugby |
| Toulon | Montpellier |
| Wasps RFC | Toulouse |
| Munster Rugby | Castres Olympique |
| Saracens | Cardiff Blues |
| Racing-Metro 92 | Leicester Tigers |
|
Round 3 B - Scadenza: 07/12/18, h.20
| Edinburgh Rugby | Newcastle Falcons |
| Llanelli Scarlets | Ulster Rugby |
| Exeter Chiefs | Gloucester |
| Lyon Rugby | Glasgow Warriors |
| Bath Rugby | Leinster Rugby |
| Toulon | Montpellier |
| Wasps RFC | Toulouse |
| Munster Rugby | Castres Olympique |
| Saracens | Cardiff Blues |
| Racing-Metro 92 | Leicester Tigers |
|
Round 4 - Scadenza: 14/12/18, h.20
| Gloucester | Exeter Chiefs |
| Ulster Rugby | Llanelli Scarlets |
| Cardiff Blues | Saracens |
| Glasgow Warriors | Lyon Rugby |
| Toulouse | Wasps RFC |
| Castres Olympique | Munster Rugby |
| Leinster Rugby | Bath Rugby |
| Leicester Tigers | Racing-Metro 92 |
| Montpellier | Toulon |
| Newcastle Falcons | Edinburgh Rugby |
|
Round 5 - Scadenza: 11/01/19, h.20
| Gloucester | Munster Rugby |
| Leinster Rugby | Toulouse |
| Montpellier | Newcastle Falcons |
| Bath Rugby | Wasps RFC |
| Ulster Rugby | Racing-Metro 92 |
| Llanelli Scarlets | Leicester Tigers |
| Toulon | Edinburgh Rugby |
| Exeter Chiefs | Castres Olympique |
| Glasgow Warriors | Cardiff Blues |
| Lyon Rugby | Saracens |
|
Round 6 - Scadenza: 18/01/19, h.20
| Edinburgh Rugby | Montpellier |
| Newcastle Falcons | Toulon |
| Cardiff Blues | Lyon Rugby |
| Saracens | Glasgow Warriors |
| Leicester Tigers | Ulster Rugby |
| Racing-Metro 92 | Llanelli Scarlets |
| Castres Olympique | Gloucester |
| Munster Rugby | Exeter Chiefs |
| Toulouse | Bath Rugby |
| Wasps RFC | Leinster Rugby |
|
